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Available April 2019
 

Liver Cancer Test

The IvyGene Liver Test is a simple blood draw that may confirm the presence of liver cancer as early as stage 1. Individuals with cirrhosis, hepatitis, or non-alcoholic fatty liver disease may be at risk for developing liver cancer.

“For people with early-stage liver cancers who have a liver transplant, the 5-year survival rate is in the range of 60% to 70%.”
-American Cancer Society

By confirming the presence of cancer earlier, survival rates may increase.

 

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How Prevalent is Liver Cancer in America?

Liver cancer is one of the most common cancers among men and women, however the ability to confirm the presence of cancer early strongly affects the survival rate.

In 2018, it is estimated that 42,000 individuals in the United States will be diagnosed with liver cancer and 30,000 individuals will die of this cancer. The incidence of liver cancer has more than tripled since 1980. This information can be found on The American Cancer Society’s website

The average 5-year survival rate for liver cancer is around 18%. This is highly affected by the stage in which the cancer is identified. For individuals diagnosed with an early stage liver cancer, the 5-year survival rate is 31%. If individuals are diagnosed with liver cancer after local metastasis, the 5-year survival rate drops to 11%, or with distant metastasis the rate drops to 3%. Statistics adapted from the American Cancer Society’s (ACS) publication, Cancer Facts & Figures 2018, and the ACS website.

A new liver cancer test, the IvyGene Liver test, is a simple blood test that uses advanced DNA sequencing methods to test for liver cancer and confirm the presence of liver cancer, as early as stage 1.

Why use the IvyGene Liver test?

The IvyGene Liver test is a highly sensitive and specific blood test that confirms the presence of liver cancer, as early as stage 1. This blood test provides a highly accurate, non-invasive complimentary tool to the current standards of care.

Current liver cancer tests available on the market today, do not offer a potent combination of high sensitivity and specificity, many only have one or the other. The IvyGene Liver test provides patients with cirrhosis or hepatitis a great tool to confirm the presence of liver cancer, before it becomes life threatening.

With a low false negative rate, patients and physicians may rely on the IvyGene Liver test for a more accurate confirmation of cancer presence and streamline the diagnosis process.

The test currently meets FDA requirements for a Laboratory Developed Test (LDT). Our laboratory is CLIA Registered (Clinical Laboratory Improvement Amendments) and CAP Accredited (College of American Pathologists).[/vc_column_text][/vc_column][/vc_row]

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Cirrhosis

What is cirrhosis?

Cirrhosis is a late stage of scarring of the liver caused by different liver diseases and conditions. When the liver is injured by hepatitis, excessive alcohol consumption, or other causes, it tries to repair itself. This creates scar tissue on the liver. As cirrhosis progresses, the scar tissue accumulates making it harder and harder for the liver to function properly. This damage almost always is permanent.
Liver Cancer Test

What are the symptoms of cirrhosis?

Symptoms of cirrhosis don’t always show themselves early on. Damage if often done by the time the patient may experience these symptoms:

  • Fatigue
  • Loss of appetite
  • Weight loss
  • Nausea
  • Swelling in the legs, feet, or ankles
  • Itchy skin
  • Easy bleeding or bruising
  • Jaundice
  • Fluid accumulation in the abdomen
  • Redness in the palms of the hands
  • Development of spider veins
  • Loss of menstrual periods for women
  • Loss of sex drive, testicular atrophy, and breast enlargement for men
  • Confusion, drowsiness, slurred speech

How is cirrhosis diagnosed?

Since early-stage cirrhosis usually doesn’t show symptoms, the condition is usually first detected through a routine blood test during a checkup. To confirm the initial blood test, other tests may be ordered:

  • Lab tests — Tests will look for signs of liver malfunction, such as excess bilirubin and certain enzymes. The blood is checked for creatinine.
  • Imaging tests — Magnetic resonance elastography may be used to detect hardening of the liver. MRIs, CT scans, or ultrasound may also be used.
  • Biopsy — Although not usually necessary for diagnosis, biopsy will show the severity, cause, and extent of the damage.

How common is cirrhosis?

The numbers of people with cirrhosis are hard to judge, as the early stages of disease don’t exhibit symptoms. Still, over 31,000 people in the U.S. die from cirrhosis every year, making it the 12th leading cause of death.

How often does cirrhosis turn into liver cancer?

From 2000 to 2015, death rates for chronic liver disease and cirrhosis in the United States increased 31% (from 20.1 per 100,000 to 26.4) among persons aged 45–64 years.

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Hepatitis

What is hepatitis B?

Hepatitis B is a serious liver infection caused by the hepatitis B virus. If a person has hepatitis B it increases his or her risk of developing liver cancer or cirrhosis and of having liver failure. There is no cure for hepatitis B and it can be chronic (lasting over six months), although most adults will fully recover.

How is hepatitis B spread?

Hepatitis B is spread from person to person through blood, semen, or other bodily fluids. This can be through unprotected sexual contact with someone who is infected, through the sharing of needles, from accidental needle sticks for health care workers, and from mother to child.

What are the symptoms of hepatitis B?

  • Abdominal pain
  • Dark urine
  • Fever
  • Joint pain
  • Loss of appetite
  • Nausea and vomiting
  • Weakness and fatigue
  • Jaundice

What is hepatitis C?

Hepatitis C is a viral infection that causes liver inflammation and can lead to serious liver damage. The virus spreads through contaminated blood, although symptoms can take decades to appear. The age group born between 1945 and 1965 is advised to be tested for hepatitis C, as they are five times more likely to be infected than those born in other years.

How is hepatitis C spread?

Hepatitis C is spread when blood contaminated with the virus enters the blood stream of an uninfected person.

What are the symptoms of hepatitis C?

  • Easy bleeding and bruising
  • Fatigue
  • Loss of appetite
  • Jaundice
  • Dark urine
  • Itchy skin
  • Fluid buildup in the abdomen
  • Swelling in the legs
  • Weight loss
  • Confusion, drowsiness, and slurred speech
  • Spider vein development

When is hepatitis considered chronic?

Chronic hepatitis B lasts six months of longer. Hepatitis C begins with an acute phase, but it rarely shows symptoms. Not all cases of hepatitis C move from acute to chronic as some people clear the virus from their bodies.

How often does hepatitis become liver cancer?

People with hepatitis B and hepatitis C have the greatest risk of liver cancer, according to the Centers for Disease Control. In the U.S., approximately 65 percent of liver cancer cases are related to hepatitis B or C, with nearly 50 percent attributable to hepatitis C alone.

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Fatty liver disease

What is fatty liver disease?

Fatty liver disease means you have extra fat in your liver. A normal liver has small amounts of fat in it, but when too much fat accumulates it can become a health problem and cause long-term liver damage. In early, mild forms, fatty liver can be reversed with changes in diet, weight loss, and increased physical activity. When it progresses, inflammation caused by the fat accumulation can lead to liver scarring, liver cancer, and liver disease.

How is fatty liver disease treated?

There are not any medications currently available to treat either fatty liver disease or NAFLD, although some are in clinical trials. If you have alcoholic fatty liver disease, quitting drinking is the only way to stop the progressing damage.

If you have NAFLD due to obesity or unhealthy eating habits, your treatment options are to manage your cholesterol, and to reduce your intake of sugars and saturated fats. You’ll need to lose weight and exercise regularly.

What causes fatty liver disease?

Heavy drinking is behind most cases of fatty liver disease. Over time, excessive alcohol consumption leads to a buildup of fat inside the cells of the liver.

However, non-drinkers can also get what is known as nonalcoholic fatty liver disease (NAFLD). The causes aren’t fully understood, but it is thought development of NAFLD is influenced by these factors:

  • Large waist size
  • High triglycerides or LDL cholesterol
  • Low levels of HDL (good) cholesterol
  • High blood pressure
  • High blood sugar
  • Having hepatitis C

How often does fatty liver disease become liver cancer?

Fatty liver disease can progress into liver disease, cirrhosis, or liver cancer. The numbers aren’t well known because NAFLD is difficult to diagnose and many people have the condition but do not know it.
Liver Cancer Test

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What are the risk factors for developing liver cancer?

Because Liver cancer doesn’t display symptoms early on, the development of a blood test provides an effective way to confirm it early. When symptoms do occur, they may include:

        1. Cirrhosis — Chronic alcohol abuse and hepatitis can cause this irreversible condition that causes scar tissue to form in the liver and increases the chances of developing liver cancer.
        2. Chronic infection with hepatitis — Chronic infection with hepatitis B and hepatitis C increases liver cancer risks.
        3. Inherited diseases such as Wilson’s disease
        4. Diabetes
        5. Nonalcoholic fatty liver disease
        6. Exposure to aflatoxins — Aflatoxins are poisons produced by molds growing on crops that aren’t stored correctly.
        7. Excessive alcohol consumption — Consuming more than moderate amounts of alcohol daily over years can damage the liver and increase the risk for liver cancer.

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What are the symptoms of liver cancer?

There are certain factors that increase a person’s risk of developing liver cancer:

        1. Weight loss
        2. Loss of appetite
        3. Nausea and vomiting
        4. Abdominal swelling
        5. Jaundice
        6. White, chalky stools

How is liver cancer diagnosed?

        1. Liquid Biopsy — Liquid biopsies are demonstrated to provide information about a patient’s health for multiple diseases.
        2. Imaging tests — Ultrasound, computerized tomography (CT) scans, and magnetic resonance imaging are used to detect liver cancer.
        3. Biopsy of liver tissue — During a liver biopsy, a doctor inserts a thin needle through your skin into the liver to obtain a tissue sample. The sample is then examined to look for cancer cells specific to liver cancer.

Have Additional Questions? View our FAQs

For more information about the Ivygene Liver Cancer Test you can call us at (844) 489-4363 or Send us an email directly.

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